Antioxidants balances the cell-damaging effects of free radicals. Bakaeen FG, Gaudino M, Whitman G, et al. 2002;8(3):CR202-CR205. In this article, weve talked about what causes excess mucus in the throat and how to get rid of phlegm in a range of different ways. J Natl Cancer Inst 2006;98:974-83. For example, in smooth muscle cells, the cellular treatment with hydrogen peroxide resulted in an upregulation of microRNA-21 [121]. View abstract. Moreover, we know that HTTP (HyperText Transfer Protocol) is a TCP/IP communication protocol used for data exchange on the web. The ability of oxidants to act as second messengers is a significant aspect of their physiological activity. These include bacteria, viruses, and parasites. Lin Y, Liu X, Cheng Y, Yang J, Huo Y, Zhang C. Involvement of MicroRNAs in hydrogen peroxide-mediated gene regulation and cellular injury response in vascular smooth muscle cells. Available at: https://wayback.archive-it.org/7993/20171114183712/https://www.fda.gov/Food/IngredientsPackagingLabeling/LabelingNutrition/ucm168527.htm. This is perhaps understandable given that glutathione peroxidase and SOD are two different antioxidant systems. Li J, Johnson JA. View abstract. Superoxide dismutase neutralizes superoxide ions by going through successive oxidative and reductive cycles of transition metal ions at its active site. The most important free radicals in many disease states are oxygen derivatives, particularly superoxide anion and the hydroxyl radical. Depending upon the binding site present in the promoter region, different antioxidant genes are induced. doi:10.1016/0021-9150(88), 8. These multiple actions make melatonin a potentially useful agent in the treatment of neurological disorders that have oxidative damage as part of their etiological basis [171]. View abstract. Nutr.Cancer 2003;46(2):125-130. FASEB J 2009;23(9):3233-3242. Aliment.Pharmacol Ther 7-15-2006;24(2):281-291. View abstract. View abstract. Selenium: A sole treatment for erosive oral lichen planus (Randomized controlled clinical trial). ScientificWorldJournal 2010;10:990-6. Output: '3.141.0' Webdriver Manager for Python: Previously, We should download binary chromedriver and Unzip it somewhere on our PC and also set a path. Carcillo, J. Their overexpression is also responsible for the activation of PKC and dephosphorylation of serine and threonine residues in DNA binding domain of c-Jun [114, 115]. Frank, J. E. Diagnosis and management of G6PD deficiency. The levels of antioxidant can be increased by supplementation, but increasing the levels of antioxidant enzymes requires activation of Nrf2 by ROS/RNS-dependent and independent mechanisms [47]. doi:10.1016/j.jtcvs.2021.04.052, 3. 2016;172(2):282-9. The aim of this review is to emphasize with current information the importance of antioxidants which play the role in cellular responce against oxidative/nitrosative stress, which would be helpful in enhancing the knowledge of any biochemist, pathophysiologist, or medical personnel regarding this important issue. In a turn around to this, the pro-oxidant effect of low levels of tocopherol is evident at low oxygen tension [196]. Here are 10 science-backed ways to increase sperm count and enhance overall fertility in men. There are four different Se-dependent glutathione peroxidases present in humans, and these are known to add two electrons to reduce peroxides by forming selenole (Se-OH) and the antioxidant properties of these seleno-enzymes allow them to eliminate peroxides as potential substrates for the Fenton reaction. Pharmacol Toxicol 1990;67:120-2. View abstract. Drse S, Brandt U, Wittig I. Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation. J Am Coll Nutr 1998;17:75-8. Regulation of Nrf2 an update. Am J Clin Nutr 2012;96(1):111-22. Taking niacin plus simvastatin along with selenium and other antioxidants can decrease the effects of niacin and simvastatin on good cholesterol levels. Serum selenium and glutathione peroxidase-3 activity: biomarkers of systemic inflammation in the critically ill? Hum.Nutr.Clin.Nutr. Heart disease and stroke statistics-2021 update: a report from the American heart association. Epilepsy Res 2002;48:71-5. var jsonReq = JSON.parse (pm.request.body.raw); var jsonReq1 = JSON.parse (request.data); Now we can write json path to extract value and do all assertions. 31. Similar to other three MAPKs, BMK-1 has been shown to be activated various extracellular stimuli such as epidermal growth factor, IL-6, and hypoxia and regulated by MAPK cascade. It also supports your efforts to reduce excessive phlegm production. Watanabe C, Kim CY, Satoh H. Tissue-specific modification of selenium concentration by acute and chronic dexamethasone administration in mice. Analyst 1998;123:3-6. Oxidation of this residue to sulfenic acid by hydrogen peroxide renders the tyrosine phosphatases inactive. Have questions about infertility tests, treatments, or lifestyle factors? Results were considered significant if p0.05. Baum MK, Campa A, Lai S, et al. Baldwa VS, Bhandari CM, Pangaria A, Goyal RK. Health News and Information, Delivered to Your Inbox, Coronary artery bypass graft (CABG) surgery. Effect of reproduction on the bioavailability of calcium, zinc and selenium. Instead, try the following coughing technique to help with getting rid of phlegm. But very high amounts can cause diarrhea, abdominal pain, and nausea. Duntas, L. H. Environmental factors and autoimmune thyroiditis. The companys Prenatal Multivitamin contains 12 essential nutrients for before and during pregnancy, including DHA, vitamin B12, folate, and choline. Alehagen U, Aaseth J, Johansson P. Reduced cardiovascular mortality 10 years after supplementation with selenium and coenzymeQ10 for four years: follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly citizens. Yu, S. Y., Zhu, Y. J., Li, W. G., Huang, Q. S., Huang, C. Z., Zhang, Q. N., and Hou, C. A preliminary report on the intervention trials of primary liver cancer in high-risk populations with nutritional supplementation of selenium in China. Evaluation of local trace element status and 8-Iso-prostaglandin F2 concentrations in patients with Tinea pedis. Biomed Khim. NO. Milde D, Novak O, Stu ka V, et al. 2022 The Author(s). The effects of selenium supplementation on gene expression related to insulin and lipid metabolism, and pregnancy outcomes in patients with gestational diabetes mellitus: a randomized, double-blind, placebo-controlled trial. But it's not clear if this is a real concern. View abstract. This might decrease the normal activity of selenium, possibly resulting in symptoms of selenium deficiency. Koskelo EK. Elsendoorn, T. J., Weijl, N. I., Mithoe, S., Zwinderman, A. H., Van, Dam F., De Zwart, F. A., Tates, A. D., and Osanto, S. Chemotherapy-induced chromosomal damage in peripheral blood lymphocytes of cancer patients supplemented with antioxidants or placebo. An assessment of 4 studies involving more than 20,000 total participants found that selenium supplementation did not reduce the likelihood that people would develop type 2 diabetes. Careers. Am J Clin Nutr 1989;50:136-40. The company also offers a supplement designed to improve fertility for women, which can be purchased separately or as a bundle. Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease. 2021;143(8):e254e743. Oxidative stress and oxidative damage in carcinogenesis. The fetched data body contain the following details: X-axis position from the top-left corner of the element; Want to support the Selenium project? Biol Trace Elem Res. Superoxide dismutase (EC 1.15.1.1) is one of the most potent intracellular enzymatic antioxidants and it catalyzes the conversion of superoxide anions to dioxygen and hydrogen peroxide: The hydrogen peroxide is removed by catalase or glutathione peroxidase, as described above. PFAS in diet and other sources: The health risks. Flohe, L. Selenium in mammalian spermiogenesis. The role of Vitamin E - Selenium - Folic Acid Supplementation in Improving Sperm Parameters After Varicocelectomy: A Randomized Clinical Trial. will also be available for a limited time. View abstract. Top, Copyright 2022 Dove Press Ltd Does dietary intake of selenium protect against cancer? Selenium plays an important role in the health of your immune system. Calcif Tissue Int 1996;59:352-6. In our study, we have found that compared to healthy subjects, patients with ICM have a significantly lower selenium status, while inflammation levels were significantly higher and there was a significant correlation between selenium and inflammatory response. JAMA 2013;310(20):2154-63. Some medications, such as those used after a transplant, decrease the activity of the immune system. Seo MY, Lee SM. Allergy 2008;63(7):865-871. Huang, J., Frohlich, J., and Ignaszewski, A. P. The impact of dietary changes and dietary supplements on lipid profile. View abstract. Li K, Zhong C, Wang B, He J, Bi J. Nrf2 expression participates in growth and differentiation of endometrial carcinoma cells in vitro and in vivo. Furthermore, ascorbic acid can be oxidized in the extracellular environment in the presence of metal ions to dehydroascorbic acid, which is transported into the cell through the glucose transporter (Fig. View abstract. A biochemical basis for transducing extracellular signals into an intracellular event has long been the subject of enormous interest. Nutrition 2014;30(9):1081-4. Zimmermann, T., Albrecht, S., Kuhne, H., Vogelsang, U., Grutzmann, R., and Kopprasch, S. [Selenium administration in patients with sepsis syndrome. But there is not enough data to support the use of any vitamin, herb, or other supplement to treat or prevent this illness. PLoS One. Glutathione peroxidases catalyse the oxidation of glutathione at direction of a hydroperoxide, which may be hydrogen peroxide or another species such as a lipid hydroperoxide: Other peroxides, including lipid hydroperoxides, can also act as substrates for these enzymes, which may hence play a role in repairing damage resulting from lipid peroxidation. The fact, that several cancers exhibit induced Nrf2 levels associated with enhanced tumor progression and chemotherapy resistance, whereas the lack of Nrf2 has opposite effects, Nrf2 represents a promising target for cancer therapies. Dtsch.Med Wochenschr. View abstract. Cureus. Alehagen U, Johansson P, Aaseth J, Alexander J, Brismar K. Increase in insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 after supplementation with selenium and coenzyme Q10. J Cardiovasc Risk 1996;3:42-7. An imbalance in generating and eliminating reactive oxygen species (ROS) and its intermediates causes oxidative stress. Upon request, the company will provide a certificate of analysis (COA), which is a document that includes detailed testing results for each supplement. An increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status. A zinc deficiency can weaken the immune system by impairing the formation, activation, and maturation of lymphocytes, white blood cells that are an active part of the immune system. Available at: https://www.nap.edu/books/0309069351/html/. This enzyme is present in the peroxisome of aerobic cells and is very efficient in promoting the conversion of hydrogen peroxide to water and molecular oxygen. J Natl Cancer Inst. REST API testing is not very difficult compared to selenium web driver UI testing. The most thiol antioxidant is the tripeptide glutathione (GSH), which is a multifunctional intracellular antioxidant. Srivastava, K. C. Ascorbic acid enhances the formation of prostaglandin E1 in washed human platelets and prostacyclin in rat aortic rings. Combs, G. F., Jr., Clark, L. C., and Turnbull, B. W. Reduction of cancer risk with an oral supplement of selenium. However, ROS/RNS are two-faced products [2]. 2019;192(1):39. Circu ML, Aw TY. Many growth factor and cytokine receptors bearing cysteine-rich motifs can be targets of oxidative/nitrosative stress. Now, the biomarkers of oxidative/nitrosative stress/damage and the methods used to measure them to determine an individuals oxidative status in relation to disease conditions frequently vary among studies, making comparisons of study findings difficult. S-nitrosylation was also associated with increased superoxide production from complex I. Yoshida S, Katoh T, Tetsuka T, Uno K, Matsui N, Okamoto T. Involvement of thioredoxin in rheumatoid arthritis: its costimulatory roles in the TNF-alpha-induced production of IL-6 and IL-8 from cultured synovial fibroblasts. Pediatr Cardiol 2012;33(5):834-8. View abstract. Urinary selenium excretion in patients with cervical uterine cancer. Eur J Clin Nutr 2001;55(4):293-297. Kojo S. Vitamin C: basic metabolism and its function as an index of oxidative stress. Am J Clin Nutr 1986;44:659-63.. View abstract. As a member of MAPK family, BMK-1 has also been linked to various cellular events including proliferation, migration, and apoptosis [136]. Further, the significant reductions in toxicity may alleviate dose-limiting toxicities to such an extent that more patients successfully complete prescribed regimens. Nakamura H, De Rosa S, Roederer M, Anderson MT, Dubs JG, Yodoi J, Holmgren A, Herzenberg LA, Herzenberg LA. This supplement from Nordic Naturals makes it easy to meet your needs, with 830 mg of omega-3 fatty acids in each serving, along with a good amount of vitamin D. These softgels are also third-party tested, non-GMO, and certified sustainable. Hofbauer LC, Spitzweg C, Magerstadt RA, Heufelder AE. Lennicke C, Rahn J, Lichtenfels R, Wessjohann LA, Seliger B. Redox proteomics: Methods for the identification and enrichment of redox-modified proteins and their applications. On the other hand, hydroquinone and tert-butyl hydroquinone, prototypes of phenolic antioxidants, block lipopolysaccharide-induced transcription of TNF and NF-kB as they block the formation of NF-kB/DNA binding complexes [102]. The rate constant for the reactions described above is extremely high (~107M/sec), implying that it is virtually impossible to saturate the enzyme in vivo. Vinceti M, Filippini T, Del Giovane C, et al. If you agree to our use of cookies and the contents of our Privacy Policy please click 'accept'. Arch Intern Med 1999;159:748-54. Zhou JY, Liu Y, Wu GS. This included dietary ideas, as well as some other ways to help jam the brakes on spiraling mucus production. doi:10.1055/s-0035-1569276, 18. Selenium is a powerful mineral that is essential for the proper functioning of your body. Code to get Request Body:-var jsonReq = JSON.parse(pm.request.body.raw); var jsonRes = pm.response.json(); To print just put in console.log(). Wood, L. G., Fitzgerald, D. A., Lee, A. K., and Garg, M. L. Improved antioxidant and fatty acid status of patients with cystic fibrosis after antioxidant supplementation is linked to improved lung function. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant sources. However, it is unlikely that antioxidants impair physiologically essential signaling pathways. View abstract. Bleys J, Navas-Acien A, Guallar E. Serum selenium levels and all-cause, cancer, and cardiovascular mortality amoung US adults. Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure. Thus ROS/RNS significantly inhibit activity of tyrosine phosphatases, resulting in increased tyrosine phosphorylation [128]. Bethesda, MD 20894, Web Policies Am J Vet Res 1983;44:1877-83. Only vaccines, together with strict hygiene measures, are proven to help prevent COVID-19. Crit Care 2006;10(6):R153. View abstract. It also provides a range of important nutrients to support a healthy pregnancy in a single capsule, including DHA, iron, vitamin B12, and folate. 2014;20(6):11101119. View abstract. Hurst R, Hooper L, Norat T, et al. official website and that any information you provide is encrypted Written informed consent was obtained from all patients to use their clinical data in this study. Nonetheless, this will be our next project. Lloyd RV, Hanna PM, Mason RP. Berger, M. M., Eggimann, P., Heyland, D. K., Chiolero, R. L., Revelly, J. P., Day, A., Raffoul, W., and Shenkin, A. Dietary Supplements and Risk of Cause-Specific Death, Cardiovascular Disease, and Cancer: A Systematic Review and Meta-Analysis of Primary Prevention Trials. B., Wasowicz, W., and Chodynicka, B. Selenium supplementation, soluble tumor necrosis factor-alpha receptor type 1, and C-reactive protein during psoriasis therapy with narrowband ultraviolet B. Yamamoto Y, Gaynor RB. View abstract. Neve J. Simultaneous Activation of Nrf2 and Elevation of Dietary and Endogenous Antioxidant Chemicals for Cancer Prevention in Humans. One-year antioxidant supplementation with beta-carotene or selenium for patients infected with human immunodeficiency virus: a pilot study. Selenium and prostate cancer: Systematic review and meta-analysis. Cancer Res 1989;49:3020-3. Inhibition of hepatic mixed-function oxidase enzymes in mice by acute and chronic treatment with selenium. Our findings revealed that plasma selenium levels were significantly correlated with the risk of ICM and serum levels of IL-6, MDA, TNF- and neutrophil/lymphocyte ratio were significantly higher in patients with ICM than in controls. Many of ROS/RNS-mediated responses protect cells against oxidative/nitrosative stress and maintain redox homeostasis. Cells communicate with each other and respond to extracellular stimuli through biological mechanisms called cell signalling or signal transduction. Orndahl G, Grimby G, Grimby A, et al. These sequential events ultimately lead to either normal cell proliferation or development of cancer inflammatory conditions, aging, and two common agerelated diseases diabetes mellitus and atherosclerosis [4043]. Rubartelli A, Bonifaci N, Sitia R. High rates of thioredoxin secretion correlate with growth arrest in hepatoma cells. Oxidative stress and inflammation have been linked to atherosclerosis, or the buildup of plaque in arteries. View abstract. 2004;61(7):760-763. Wasowicz W, Gromadzinska J, Szram K, et al. doi:10.1016/0192-0561(83)90022-x, 24. JAMA 1991;265:2688-91. Leatherdale B, Panesar RK, Singh G, et al. What are the pros and cons of this approach to healthcare? If a person already has a deficiency, they likely need more of that nutrient than a multivitamin contains. If you have a persistent cold and phlegm that refuses to budge, it might be time to make a trip to your local pharmacy to pick up a decongestant or vapor rub. Ji XJ, Chen SH, Zhu L, Pan H, Zhou Y, Li W, You WC, Gao CC, Zhu JH, Jiang K, Wang HD. Later found out that we can easily install latest version of Selenium WebDriver Support Classes by running the command: Install-Package Selenium.Support Do you feel congested after drinking alcohol? 2016;48(4):263-8. Bertolini, G., Iapichino, G., Radrizzani, D., Facchini, R., Simini, B., Bruzzone, P., Zanforlin, G., and Tognoni, G. Early enteral immunonutrition in patients with severe sepsis: results of an interim analysis of a randomized multicentre clinical trial. Within a week of blood collection, the plasma samples were used to measure selenium using an atomic emission photoelectric optical emission spectrometer (AFS-930, Beijing).12,13. 2020;20(1):457. Patients with ICM were recruited for the study by clinicians based on expert consensus on ICM 2020.2 ICM is defined as LV dysfunction caused by CAD, with or without clinical HF.2 The inclusion criteria for subjects selected as the control group were as follows. Sci Rep. 2016;6:19213. View abstract. Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2. Myocardial Viability Assessment Before Surgical Revascularization in Ischemic Cardiomyopathy: JACC Review Topic of the Week. Debski B, Milner JA. View abstract. Studies challenging the molecular basis of the Keap1-Nrf2 system functions are now critically important to improve translational studies of the system. Biol Trace Elem Res 2019;191(2):331-7. doi: 10.1007/s12011-019-1636-7. J Am Coll Nutr 2005;24:250-6. Kung AWC, Pun KK. The effect of ROS/RNS on the process of cell signaling is promoted through a number of simultaneous mechanisms and, most commonly, by activating an extensive network of various interactive intracellular signal transduction pathways (Fig. Int J Cardiol 2013;167(5):1860-6. Circ J. Inflamm Bowel Dis. Thyroid 2016;26(12):1681-92. View abstract. Safarinejad, M. R. and Safarinejad, S. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. This can cause you to cough up the excess phlegm thats gathered overnight.22. However, providing your body with the best possible nutrition including vitamins and minerals is one area where you can take the reins. While most studies show that taking vitamin C does not prevent colds in the general population, it may help reduce the symptoms and severity of a cold. Robinson, M. F., Campbell, D. R., Stewart, R. D., Rea, H. M., Thomson, C. D., Snow, P. G., and Squires, I. H. Effect of daily supplements of selenium on patients with muscular complaints in Otago and Canterbury. View abstract. Verrotti A, Basciani F, Trotta D, et al. The study was approved by the Ethical Committees of Central Hospital of Enshi Tujia and Miao Autonomous Prefecture. An Italian multicenter double-blinded randomized study between single or combination therapy (PROCOMB trial). View abstract. All NF-kB/REL proteins contain a Ref-1-homology domain (RHD), which is responsible for dimerization, recognition and binding to DNA as well as interaction with the inhibitory kB (IkB) proteins. Combs GF Jr. Selenium in global food systems. But having a weakened immune system can increase the risk of delayed wound healing, infectious illnesses such as colds, and other infections. Advances in the field of biochemistry including enzymology have led to the use of various enzymes as well as endogenous and exogenous antioxidants having low molecular weight that can inhibit the harmful effect of oxidants. Prostate 2014;74(15):1471-80. Clin.Chim.Acta 1-31-1995;234(1-2):137-146. To get the bad stuff away from your lungs, phlegm has to keep moving. Analysis of sulfur and selenium assimilation in Astragalus plants with varying capacities to accumulate selenium. View abstract. View abstract. Morgia G, Russo G, Voce S, et al. J Int Assoc.Physicians AIDS Care (Chic.) Sb Lek 2000;101:241-8.. View abstract. Some have argued that antioxidants scavenge the ROS/RNS integral to the activity of certain chemotherapy drugs, thereby diminishing treatment efficacy. One dollar sign means the product is rather affordable, whereas four dollar signs indicate a higher cost. 8600 Rockville Pike Wang S, Yan R, Wang B, Meng P, Tan W, Guo X. We weigh the evidence pro and against. Children, young women and elders are the most exposed. 2004;(4):CD004183. Federico, A., Iodice, P., Federico, P., Del Rio, A., Mellone, M. C., Catalano, G., and Federico, P. Effects of selenium and zinc supplementation on nutritional status in patients with cancer of digestive tract. 2004-2022 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Serum levels of selenium, manganese, copper, and iron in colorectal cancer patients. J Epidemiol Commun Health 1983;37:213-7. Dillard CJ, Tappel AL. In addition to key nutrients like vitamin D, iron, and vitamin B12, this product contains ingredients such as myo-inositol, which may be beneficial for improving fertility (7). View abstract. Biol Trace Elem Res 2001;79:97-105.. View abstract. View abstract. Contact Us Kamali A, Amirani E, Asemi Z. Here, we use Pythons request library to make a get request to the URL and save the requests response, i.e., page source to an HTML file and print on the terminal. Finley JW, Ip C, Lisk DJ, et al. A randomized controlled trial. Ciliberto, H., Ciliberto, M., Briend, A., Ashorn, P., Bier, D., and Manary, M. Antioxidant supplementation for the prevention of kwashiorkor in Malawian children: randomised, double blind, placebo controlled trial. Czernichow, S., Couthouis, A., Bertrais, S., Vergnaud, A. C., Dauchet, L., Galan, P., and Hercberg, S. Antioxidant supplementation does not affect fasting plasma glucose in the Supplementation with Antioxidant Vitamins and Minerals (SU.VI.MAX) study in France: association with dietary intake and plasma concentrations. Infertility is something many men experience. Avenell A, Noble DW, Barr J, Engelhardt T. Selenium supplementation for critically ill adults. The author wish to thank Dr. Yakup Gumusalan for pre-reviewing this manuscript. Salonen JT, Alfthan G, Huttunen JK, Pikkarainen J, Puska P. Association between cardiovascular death and myocardial infarction and serum selenium in a matched-pair longitudinal study. All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work. Int.J Cancer 9-15-2008;123(6):1227-1239. However, things like smoking, alcohol use, and stress can cause an excess of free radicals. Urol J. View abstract. Since DHLA neutralizes free radicals it is known to regenerate Vitamin C which is even better than GSH and Vitamin E from their oxidized forms. While youre still and sleeping, phlegm can pool and settle in your lungs and throat. Crit Care Med. http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/. Bhupesh started his career as a Clinical Toxicologist for Public Health England, advising healthcare professionals all around the country on how to manage clinical cases of adverse exposure to supplements, pharmaceuticals, cosmetics, industrial chemicals and agricultural products. As presented in Table 2, when the matched data for plasma selenium and indicators of inflammation and oxidative stress were compared between groups, plasma selenium levels were significantly lower in the ICM group than in the control group, and indicators of inflammation such as TNF-, IL-6 and neutrophil/lymphocyte ratio were significantly higher in the ICM group than in the control group (all of these results were statistically different).
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